Common symptoms of an autoimmune disorder can widely vary as these conditions can affect any part of the body, but there are some general signs that may indicate an immune system issue. These include fatigue, muscle aches, swelling and redness, low-grade fever, trouble concentrating, numbness and tingling in the hands and feet, hair loss, and skin rashes. More specific symptoms can occur depending on the type of autoimmune disorder, such as difficulty breathing in asthma, or sudden sneezing, runny nose, and itchy eyes in allergies.