What Are the Potential Side Effects of KRYSTEXXA for Gout Treatment?
Like all medications, KRYSTEXXA has potential side effects, and patients should be aware of these risks before starting treatment. One of the most common side effects is gout flare-ups, especially during the initial months of treatment. These flares occur because KRYSTEXXA rapidly reduces uric acid levels, which can initially trigger the release of urate crystals from joint tissues, leading to temporary discomfort. Healthcare providers often prescribe other medications, such as non-steroidal anti-inflammatory drugs (NSAIDs), to help manage these flares.
Serious side effects include allergic reactions, which can occur during or shortly after the infusion. Signs of an allergic reaction include rash, itching, swelling, difficulty breathing, and chest tightness. In rare cases, anaphylaxis, a life-threatening allergic reaction, can occur. To reduce the risk of infusion reactions, patients may receive premedication before each KRYSTEXXA infusion. Other possible side effects include nausea, fatigue, and bruising at the infusion site. It's important for patients to discuss any concerns with their healthcare provider before starting treatment to ensure they understand the risks and benefits.
