Lymphoma is staged based on how far the Cancer has spread within the body. The stages range from I to IV, with stage I being localized and stage IV representing widespread involvement. In stage I, the lymphoma is confined to one lymph node group or a single organ outside of the lymphatic system. Stage II indicates that the lymphoma is found in two or more lymph node groups on the same side of the diaphragm, or it involves one organ and nearby lymph nodes. In stage III, lymphoma has spread to both sides of the diaphragm, involving lymph nodes and possibly organs such as the spleen.

Stage IV is the most advanced stage, where lymphoma has spread extensively throughout the body, affecting organs such as the liver, bone marrow, or lungs. The staging of lymphoma is crucial in determining the appropriate treatment plan and prognosis. In addition to the stage, the presence of symptoms such as fever, night sweats, and weight loss (often referred to as "B symptoms") can further influence the treatment approach. Staging is usually determined through imaging scans, biopsies, and other diagnostic tests to assess the extent of the disease.

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